Stem cells are being preserved in the human body during life, although over time there is a decrease in their number and functional activity. Modern technologies allow us to isolate and amplify different types of stem cells from a minimal sample of a patient’s biological material tissue and then improve their functional state in a biotechnological laboratory and multiply them to the required amount for clinical use.
The Deva Clinique medical center uses a unique technology that allows to isolate and amplify three different types of stem cells from a small sample of the patient’s skin.
Skin fibroblasts are the main type of skin cells that are responsible for the synthesis of collagen, elastin, and other components of the extracellular matrix. In this way, fibroblasts determine the texture of the skin, its elasticity, the number and severity of wrinkles.
Skin revitalization and rejuvenation through therapy with own fibroblasts was the first procedure in the world based on the use of stem cells grown outside the human body, which was approved by the U.S. Food and Drug Administration (FDA) for clinical use.
In addition, skin fibroblasts show high effectiveness in the treatment of chronic wounds and trophic ulcers.
Skin rejuvenation with fibroblasts goes in several stages. First, a punch biopsy is performed – a small sample of skin is taken from the behind-the-ear area.
Next, this skin sample – which is the basis for the fibroblast elixir of youth – is brought to Deva Clinique laboratory, where the specialists directly select active cells for further cultivation. They are placed in a nutrient solution that promotes cell division and reproduction.
Young fibroblasts are transplanted into the dermis of the skin using thin needles. Once in the dermis, the cells immediately start working – producing collagen, elastin and hyaluronic acid.
The matter is that fibroblasts are perfectly preserved at ultra-low temperatures for many years at Deva Cryobank.
Mesenchymal stem cells
Mesenchymal stem cells are localized in many tissues and organs of the body including bone marrow, adipose tissue, dermis and hypodermis of the skin. A distinguishing feature of MSCs is their ability to multilinear differentiation. This is how MSCs can turn into cells of bone, articular cartilage, tendons, ligaments, blood vessels, and so on.
MSCs are a unique and irreplaceable tool for repairing injuries and treating diseases of the musculoskeletal system (bone fractures, cartilage defects, osteoporosis, and degenerative joint changes).
In addition, MSCs have strong secretory activity and trophic effect. Such property allows these cells to stimulate the regeneration of various tissues and organs, show immunomodulatory and antiinflammatory effects. This makes stem cell therapy using autologous MSCs a powerful treatment for autoimmune, inflammatory, and degenerative diseases.
Neural crest stem cells
Neural crest stem cells – for many years, there was a paradigm in biology and medicine that neural cells do not regenerate. Stem cell presence in the nervous system, including the brain and spinal cord, was discovered in the early 90s of the last century.
In the body, neural crest stem cells are responsible for the development of the peripheral nervous system but after special processing, these cells can turn into the brain and spinal cord cells.
Thus, neural crest stem cells show high efficiency when used for the treatment of autism, cerebral palsy, stroke consequences, brain and spinal cord injuries, peripheral nerve repair, treatment of encephalopathy, dementia, multiple sclerosis, and neurodegenerative diseases (Alzheimer’s and Parkinson’s diseases).